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KMID : 0387720170280020170
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Korean Journal of Blood Transfusion
2017 Volume.28 No. 2 p.170 ~ p.176
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Revisiting the Pre-transfusion Test: A Case of Acute Hemolytic Transfusion Reaction due to Multiple Alloantibodies of Anti-E, Anti-c, Anti-Jkb
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An Gyu-Dae
Kim Kyeong-Hee
Jeong In-Hwa
Lim Hyeon-Ho
Woo Kwang-Sook
Han Jin-Yeong
Kim Jung-Man
Chung Jin-Heon
Son Young-Ki
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Abstract
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We report a case of acute hemolytic transfusion reaction due to multiple alloantibodies. A 41-year-old male with multiple histories of transfusion was admitted for jaundice and oliguria after receiving two units of red blood cells in a local clinic. He showed acute renal failure and disseminated intravascular coagulation. Direct Coombs test was negative and antibody screening test showed strong positive results. Anti-E, anti-c, and anti-Jkb antibodies were identified in two panels of unexpected antibody assays. Acute hemolytic transfusion was diagnosed, and he was discharged after 1 month of supportive treatment. Unexpected antibody detection tests, including the antiglobulin phase, should be performed to prevent adverse transfusion reactions by unexpected antibodies. Better precision and quality control are necessary when performing pre-transfusion tests.
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KEYWORD
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Hemolytic transfusion reaction, Pre-transfusion test, Unexpected antibody
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